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More recently, attention has shifted from the gut to these drugs effects in the brainspecifically, systems that regulate motivation, reward, and behavior

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The highest tirzepatide dose (15mg) produced an average weight loss of 11.2kg compared to 5.7kg with semaglutide 1mg

Once familiarization was complete, the animals were treated for 10 consecutive days (Days 514) in a randomized, placebo-controlled manner