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The Cochrane risk of bias assessment tool for randomized control trials and the NewcastleOttawa scales for cohort studies were used to assess the quality of the included studies 21,22

As for who should steer clear, and this is still being worked out, the likely list matches the rest of the class: anyone with a personal or family history of medullary thyroid cancer, multiple endocrine neoplasia type 2, severe stomach-emptying problems, severe diabetic eye disease, or pregnancy

Note that most animal studies use doses between 10 ng/kg and 10 g/kg, which corresponds to very small volumes in murine practice and imposes intermediate dilutions

Journal of the American Pharmacists Association , 52(2), e53-e63

T., Cuccolo, K., Hallward, L., & Nagata, J