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Thirdly, diet and gut microbial metabolites, including TMAO and SCFAs, can have various effects on atherosclerosis (Jonsson and Bckhed, 2017

The endoscope was advanced to the second duodenum

The FDA has specifically approved tirzepatide (Zepbound) to treat sleep apnea in certain obese patients, highlighting the medical communitys recognition of this therapeutic pathway

As a result, tamoxifen is clinically used in ER -positive breast cancers as an antagonist of estrogen signaling in mammary epithelial cells, yet it provides secondary ER -agonist effects in bone, preventing osteoporosis (Rachner et al., 2018), and in endometrium, leading to an increased risk of endometrial cancer (Braun, Overbeek-Wager, and Grumbo 2016)