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HIV-1 protein Vpr increases H 2 O 2 production and activates hypoxia-inducible factor-1, thereby stimulating HIV-1 gene transcription via hypoxia-inducible factor-1 association with the HIV-1 long terminal repeats 122

Its decline can contribute to insulin resistance, a precursor to type 2 diabetes and a significant barrier to effective weight management

Autistic children exhibit decreased levels of essential fatty acids in red blood cells

However, cysteine depletion generally induces stronger ferroptotic responses compared to GSH depletion 10 , which is suggestive of additional mechanisms underlying cysteine starvation-induced ferroptosis

Aib, H., Parvez, M