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Further research is needed to validate the efficacy and safety of these approaches in clinical settings and to identify optimal therapeutic regimens for patients with APAP overdose

however, a new paradigm for HFpEF development proposes that a systemic proinflammatory state, induced by comorbidities, is responsible for these myocardial structural and functional changes [11]

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Phase 2 detoxification is the critical step where these highly reactive intermediates are neutralized and prepared for safe excretion from the body