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This makes it an effective option for vitamin D deficiency treatment , especially when symptoms are affecting daily life

Specifically, patients were randomized in an open-label fashion to receive either: (i) PIO 30 mg/day for 2 weeks followed by PIO 45 mg/day for 50 weeks ( n = 10) or (ii) EXE 5 g twice daily and PIO 30 mg/day for 2 weeks followed by EXE 10 g twice daily and PIO 45 mg/day for 50 weeks ( n = 11)

Key labs include a CMP to assess liver enzymes and kidney function, an A1c to track glycemic control, and a lipid panel to evaluate improvements in cardiovascular risk over time

The company recently achieved two major milestones, including the successful completion of a Phase II clinical trial in 32 patients aged 12 years and older, which demonstrated a clinically meaningful reduction in hyperphagia along with a favourable safety and tolerability profile

HEK293T cells were purchased from American Type Culture Collection and HeLa cells were a gift from the Lehner laboratory (University of Cambridge)