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Individual health conditions : People with pre-existing health conditions or those taking medications should consult with their healthcare providers before using DSIP, as its effects may vary across different populations

Because insulin resistance in PCOS is a whole-body phenomenon expressed most strongly in skeletal muscle, liver, and adipose tissue, and retatrutides three signals converge on exactly those tissues indirectly, by driving large reductions in body weight and ectopic (especially hepatic) fat, and possibly directly, through incretin effects on the pancreatic islet and on adipose biology

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Diabetic cardiomyopathy: clinical phenotype and practice

Amadeo A, Bonollo L, Botto G, and et al