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The FDA has long been updating its recommendations regarding acetaminophen use to help improve patient safety

J Clin Invest 2009;119:3189202.ArticlePubMedPMC 29

Since glutamate is one of the brains major excitatory neurotransmitters, this pathway has drawn interest in conditions such as obsessive-compulsive disorder (OCD), depression, bipolar disorder, and substance use disorders.11 29 The evidence is still uneven