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P450 uses molecular dioxygen of which one oxygen atom interacts with the substrate and a second oxygen atom, with the use of two electrons provided by NAD(P)H, is reduced to a water molecule

doi: 10.1001/jama.2019.10232 12 RosaJAVan LindaBMAbourizkNN

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In these experiments, CaBPC157 (10 g or 10 ng/kg b.w.) or saline was given intraperitoneally (5.0 ml/kg) 15 minutes before bleeding or intravenously (3.0 ml/kg) after a period of 5 minutes of stable low blood pressure