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Age was recorded as a continuous variable, and sex was classified as male or female

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Primer sequences are provided in Data sheet 1 : Supplementary Table S1 (synthesized by Sangon Biotech Co., Ltd., Shanghai)

Adsorptive-mediated transport at the BBB has also been exploited to target nanocarrier systems by using cationic lipids and cell penetrating peptides to increase binding and internalization at the brain capillary endothelium [29, 30], which has a highly negative surface charge [31]

The real-world outcome