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The extended half-lives of weekly formulations mean these medications do accumulate to some degree with repeated dosing until reaching what is termed 'steady state'a predictable, stable concentration that optimises therapeutic benefit whilst minimising adverse effects

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reduced NNMT may shift these patterns toward a more metabolically active state

Clinical Update 3/27/2025 Semaglutide & Iron Absorption The GLP-1 agonist semaglutide (Ozempic, Wegovy) may reduce iron absorption from supplements, according to a recent study