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The fixed-ratio nature of the blend also means components cannot be titrated independently: any adjustment scales all four peptides together

Clinical status in time after initial isoprenaline application Prophylactic regimen Isoprenaline at 0 time and 24 h time Respiratory frequency/min, means SD Peripheral edema, scored 03, min/med/max Medication at 30 min before isoprenaline 24 h (one isoprenaline challenge) infarction 48 h (two isoprenaline challenges) reinfarction 24 h (one isoprenaline challenge) infarction 48 h (two isoprenaline challenges) reinfarction Saline 5 mL Isoprenaline 75 138 41 158 47 1/2/3 2/3/3 BPC 157 10 g 77 23 * 81 24 * 0/0/0 * 0/1/2 * BPC 157 10 ng 80 24 * 90 27 * 0/0/1 * 1/1/2 * Saline 5 mL Isoprenaline 150 144 43 133 49 1/2/3 2/3/3 BPC 157 10 g 83 25 * 93 28 * 0/0/0 * 0/1/2 * BPC 157 10 ng 95 28 * 99 29 * 0/0/1 * 1/1/2 * L-NAME 5 mg 161 48 * 177 53 * 2/3/3 * 2/3/3 * L-arginine 200 mg 92 27 * 95 28 * 0/1/2 * 1/1/2 * L-NAME 5 mg + L-arginine 200 mg 142 42 159 47 1/2/3 2/3/3 BPC 157 10 g + L-NAME 5 mg 89 26 * 94 28 * 0/0/0 * 0/1/1 * BPC 157 10 g + L-arginine 200 mg 81 24 * 92 27 * 0/0/0 * 0/1/2 * BPC 157 10 g + L-NAME 5 mg + L-arginine 200 mg 85 25 * 97 29 * 0/0/1 * 1/1/2 * Therapeutic Regimen Noxious procedure mg/kg s.c

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Hormonal and Cellular Effects (Theoretical) : Influence on growth factors and cellular signaling raises concerns about unintended effects on tissue growth or repair processes