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This two-part method not only works better than using just one agent, but it also protects against bad effects, creating an environment that is good for better muscle growth and faster recovery

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Circulation 107:13591365 Yasumura EG, Stilhano RS, Samoto VY, Matsumoto PK, de Carvalho LP, Valero Lapchik VB, Han SW (2012) Treatment of mouse limb ischemia with an integrative hypoxia-responsive vector expressing the vascular endothelial growth factor gene