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Functional and confirmatory markers Methylmalonic acid (MMA), homocysteine, and holotranscobalamin can provide information that total B12 does not

Kulick, Y.J

Interestingly, RJ pretreatment markedly reduced the expression of Bax and caspase-3, and markedly increased Bcl-2 expression compared with the Cd-treated group (Table 1)

Demonstrated Safety and Tolerability Profile 1 With RADICAVA , the most common adverse reactions were contusion, gait disturbance, and headache 1, a (see footnote) Safety profile was demonstrated in pooled placebo-controlled trials b (see footnote) in which 184 patients with ALS were administered RADICAVA (edaravone) (60 mg) in 24-week treatment cycles

Dose adjustment, protocol modification, or reevaluation of injury severity and type may be appropriate