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The therapeutic categories most affected include immunosuppressants, GLP-1 agonists for diabetes and obesity, respiratory biologics, and multiple sclerosis agents precisely the categories where manufacturers have the highest revenue concentration and where biosimilar or therapeutic alternative competition is either pending or already available
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This review systematically outlines the core mechanisms of ferroptosis and its specific impacts on OA, explores the potential of ferroptosis-related biomarkers as diagnostic and therapeutic targets, and discusses the challenges and opportunities for clinical translation
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