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In all, mTORC1 signals serve as a central hub of amino acid sensing and a variety of metabolic regulatory pathways, including proteins, nucleotides, and lipids synthesis, as well as other anabolic or catabolic processes (Ben-Sahra and Manning, Amino Acid Metabolism and Epigenetics Epigenetic modification can regulate gene expression by activating or inhibiting gene transcription without changing the DNA sequence, ultimately affecting embryonic development, stem cell differentiation, senescence, and tumorigenesis (Brien et al., 2019)

2,3 Nrf2 stays sequestered in the cytoplasm by its interaction with the Keap1 protein complex (Keap1-Kelch-like ECH-associated protein 1)

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The SURMOUNT-1 trial reported -22.5% weight reduction at the 15 mg weekly dose across 72 weeks (PMID 35658024)

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