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The robust triglyceride reduction seen at higher retatrutide doses is attributed to the glucagon receptor pathways direct stimulation of hepatic fat oxidation, which reduces hepatic VLDL secretion and subsequently lowers circulating triglyceride concentrations

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Conclusions GLP-1 RAs distinct and unique mechanism of enhancing insulin release in response to glucose, increasing satiety, and slowing gastric emptying can be attributed to the previously mentioned benefits of weight management and glycemic control