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546 Morphological atrophy of astrocytes also reduces their presence in the neuropil, which leads to an increase of extracellular diffusion channels and hence to an increase in mean diffusivity of the grey matter, detected in elderly humans with diffusion tensor imaging

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This is potentially driven by decades-long plasma platinum retention and months-long tissue platinum sequestration, which sustain platinumDNA adduct formation, genomic instability and oncogenic mutations (Hellesnes et al