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In addition to the described signaling system, mitophagy receptors BNIP3, NIX/BNIP3L10, and FUNDC1B are localized on the outer mitochondrial membrane, which interact directly with LC3 through typical or atypical LIR motifs (LC3-interacting region) independent on ubiquitination

This interaction is particularly concerning because many people dont consider over-the-counter medications when evaluating supplement safety

Each step adds receptor targets and produces incrementally better results