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The agency highlighted risks including dosing errors, contamination, and the use of unapproved salt forms in compounded versions, some of which resulted in adverse events requiring hospitalizations.[3] This followed previous statements by the FDA concerning unapproved GLP-1 drugs used for weight loss, including concerns with compounded versions of the drug, fraudulent compounded GLP-1 drugs, and versions sold falsely for research purposes or not for human consumption.[4] Import Alert 66-80 now ties enforcement to the Green List by authorizing detention without physical examination of GLP-1 API shipments from non-listed firms
PubMed lists abstracts noting reduced inflammation and improved mobility
That uncertainty compounds the fragment-versus-parent issue: two vials with the same label may not even contain the same molecule that the studies used
S-glutathiolated hepatocyte proteins and insulin disulfides as substrates for reduction by glutaredoxin, thioredoxin, protein disulfide isomerase, and glutathione