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THC therefore plays an important role in signaling across the synaptic cleft, and in the binding and activating CB1 receptor found in both the neural membranes at the synapse and in the mitochondrial membrane in the excitatory and inhibitory terminals 29

Compared with conventional formulations, NPs can provide more controlled drug release, and higher delivery precision, which may increase bioavailability and prolonged therapeutic exposure [19, 20]

Youle M, Osio M, ALCAR Study Group

Methylcobalamin is the preferred form for lipotropic protocols because it bypasses the conversion step entirely