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Which medication should I choose, semaglutide or tirzepatide
42 In the STEP 1 study, participants who achieved a mean weight loss of 10.6% after 20 weeks of semaglutide were rerandomized in STEP 4 to either continue semaglutide or switch to placebo for an additional 48 weeks
GLP-1 is no exception
Whilst GLP-1 receptor agonists primarily work by enhancing insulin secretion rather than directly improving insulin sensitivity at the cellular level, the associated weight loss that often occurs with these medications can lead to secondary improvements in insulin resistance
This is despite the fact that they had a previous study when it was just a diabetes drug that showed an effect at just 0.5mg
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