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At a synaptic or molecular level, basic electrophysiology studies and studies using food suggest that both presynaptic and postsynaptic mechanisms are likely to be involved in the effects of GLP1 receptor agonists on reward pathways (Liu & Pang, 2016

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Sometimes, doctors may suggest a lower dose if full treatment is no longer needed, or they may recommend stopping if the goals are met and can be maintained without it

While these symptoms typically improve over time, tirzepatides dual-hormone mechanism may lead to slightly more pronounced nausea for some patients, especially during the initial dose escalation