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Sufferers of pernicious anaemia, which causes memory loss, extreme fatigue and irrational behaviour, receive an NHS vitamin B12 jab every three months

Upon forming the mixed disulfide, a reaction occurs where the nitrobenzoic acid group is released as nitro-2-thiobenzoate anion (TNB ), a yellow anion

In addition, mTORC1 activation via glutaminolysis suppresses autophagy and the DNA damage response 164,165

Studies have shown that neuroinflammation can lead to increased excitability of locus coeruleus neurons, which may contribute to increased anxiety and depressive symptoms [346]

It is worth noting that one of the recently approved ALS therapies (sodium phenylbutyrate + TUDCA, as mentioned earlier) highlights the intersection of microbiome-related metabolism and neurodegeneration [224]