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This was a key mechanism for TGF-1-mediated profibrogenic effect in HSCs that is targeted by ()-epigallocatechin-3-gallate, the major constituent of green tea that exerts antioxidant effect [73]

Those that include unsaturated fatty acids remain liquid even when left out of the fridge

Considering that energy metabolism is also able to regulate ROS levels, we supplemented sodium pyruvate (the sodium salt form of pyruvate, a key energy substrate for cellular metabolism) or JX06 (a compound that modulates pyruvate flux into the tricarboxylic acid cycle) in GGCT-knockdown cells, respectively

In addition, crosstalk between ferroptosis and other forms of regulated cell death can be leveraged to maximize drug treatments

GSH-deficient cells showed increased Dnmt activity and decreased Tet hydroxylase activity (Fig