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This triple mechanism distinguishes it from existing approved treatments such as semaglutide (which targets GLP-1 alone) or tirzepatide (which targets GLP-1 and GIP)

While enhanced BBB permeability could theoretically facilitate drug entry, it also leads to uncontrolled exposure of brain tissue to circulating toxins and immune cells, complicating therapeutic delivery [163]

Step 5: Purification of compound of formula- 13 The crude compound of formula- 13 obtained in step 4 (12 gm) was dissolved in 50% methanol in water at 25-30C and sonicated

Understanding where you have a genetic susceptibility and then optimizing to avoid specific toxicants or drugs is the key here

Peptides 13(1):1316 Sandoval DA, DAlessio DA (2015) Physiology of proglucagon peptides: role of glucagon and GLP-1 in health and disease