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Moreover, in a meta-analysis of eight trials, GLP-1RAs reduced MACE by 14% (HR 0.86, 95% CI 0.790.94), cardiovascular death by 13% (HR 0.87, 95% CI 0.780.96), and stroke by 16% (HR 0.84, 95% CI 0.760.94) [22] (Table 2)
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Frequency ranges from nightly to several times per week depending on clinical goals and patient response
Recent research indicates that while these drugs significantly reduce body weight and adiposity, fat-free mass lost accounts for 25-40% of the total weight lost during therapy, raising concerns about muscle loss, which is vital for overall health and physical function
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