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[5] [6] This means that whilst Wegovy can significantly reduce hunger and help control portion sizes, the foundation of successful weight loss remains a sustainable reduction in calorie intake combined with behavioural changes
Histochem 65 (3), 3224
Insurance companies often impose their own BMI requirements (sometimes 35 or higher), which are stricter than FDA guidance
Retatrutide has reported a larger average weight-loss effect than tirzepatide (the active ingredient in Mounjaro and Zepbound) in their respective trials roughly 28% versus roughly 2122% over similar timeframes largely because retatrutide adds a glucagon receptor on top of the GIP and GLP-1 targets tirzepatide already uses
For those who cannot use GLP-1 drugs or prefer an oral medicine, there are other choices
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