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Controlled preclinical studies are crucial to deepen the understanding of these mechanisms and guide therapeutic approaches that minimize the risks of tumor metastasis and recurrence

The disconnect between this promising science and clinical application is stark: not a single human trial exists for mental health applications, leaving patients and clinicians with compelling mechanisms but zero human efficacy or safety data

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Hyperoside stabilizes mitochondrial function and prevents apoptosis by activating the PI3K/AKT pathway, further supporting melanocyte viability under oxidative stress 144