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Tolerance refers to the reduction in or loss of drug efficacy caused by long-term administration and indicated by the pharmacological changes to the right of the dose-response curve, the development and degree of which depend on the drug interactions with the opioid receptors, drug dose, and frequency of administration [15]
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Nearly 4% of users who reported side effects mentioned menstrual changes, things like irregular cycles, heavy bleeding, or intermenstrual bleeding, and these symptoms arent prominently featured in the current prescribing information. When you consider that were looking at a mixed-gender sample on Reddit, and that Reddit skews male, the true rate among women taking these medications could potentially be higher, Sehgal said
Fahey]: Yeah
