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Front Endocrinol (Lausanne) 13:1006376 Deepa Maheshvare M, Raha S, Knig M, Pal D

135 Irrespective of the patients disease stage, smoking cessation is imperative for enhancing lung function, alleviating symptoms, and slowing disease progression

and these observations may correspond to seasonal changes in solar insolation, alterations in melatonin production and seasonal influence on the hypothalamicpituitarythyroid (HPT) axis, especially at locations of increasing distance from the equator [353]

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This cautious, iterative approach is fundamental to responsible scientific inquiry