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Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]
10.1016/S0140-6736(20)30752-2
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It is evident that CNS GLP-1R signaling is essential for mediating the pharmacological action of GLP-1R agonists on energy metabolism as genetic deletion of CNS GLP-1R signaling in mice ablates the action of peripherally administered liraglutide on food intake and body weight reduction (Sisley et al., 2014)
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