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should be aware of the potential adverse effects of allodynia and dysesthesia associated with semaglutide and tirzepatide because these agents are increasingly prescribed and additional drugs in this class are in development." Dr

Additionally, vascular dysfunction, endothelial dysfunction, and microclot presence may also promote vasoconstriction and tissue hypoxia

While there is no contraindication between these medications, there are specific interactions that require attention, particularly with oral semaglutide (Rybelsus)