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There are disputes over how concerning this should be as a side effect, but some studies show as much as 40 to 60 percent of the total weight loss on GLP-1 drugs comes from lean muscle mass

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Eli Lilly Goes Direct: Zepbound Without the PBM In a move that signals growing friction between pharma manufacturers and pharmacy benefit managers, Eli Lilly announced a program to sell Zepbound its tirzepatide-based weight loss medication directly to employer health plans, bypassing PBMs altogether