It has been proposed that -tocopherol can also scavenge superoxide, as suggested by experiments with submitochondrial particles isolated from mice fed with vitamin-E supplemented diet ( Although the dismutation of superoxide by SOD2 is a predominant source of H 2 O 2 , there are other reactions that directly generate H 2 O 2 in mitochondria
doi: 10.1016/j.ecl.2008.08.006 234 FrankDNSt AmandALFeldmanRABoedekerECHarpazNPaceNR
[ deprotonation protonation, or just proton transfer ] The resulting positively charged nitrogen species is now a significantly better leaving group , since the leaving group will be HNR 2 (a weak base) instead of ()NR 2 ( a very strong base)
NMDA receptors regulate GABA A receptor lateral mobility and clustering at inhibitory synapses through serine 327 on the 2 subunit
Ruscoe JE, Rosario LA, Wang T, Gat L, Arifoglu P, Wolf CR et al