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TB-500 is dosed less frequently, typically once or twice per week during a loading phase and once every two weeks during maintenance, reflecting its longer half-life and systemic distribution pattern

Cramer DW, Wise LA: The epidemiology of recurrent pregnancy loss

This was most marked with the human growth hormone

Sigman, M., Glass, S., Campagnone, J., and Pryor, J

( Reichling and Saller 2002 ) Ten years later it was stated, "Double-blind and randomized studies versus placebo or active control found statistically significant effects of STW 5 (Iberogast) on patients symptoms with a comparable efficacy to a standard prokinetic." ( Ottillinger, et al 2012 )