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We simulated the system behavior while varying each parameter by 100fold (See Materials and Methods)

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The light energy is then converted into heat, which eliminates the hyperpigmentation and simultaneously stimulates the production of new, healthy skin cells

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Lastly, despite PDE5i treatment has been proven a cost-effective therapeutic strategy, compared to no treatment [62], the relatively high cost of a chronic treatment with some reference/equivalent pharmaceutical formulations belonging to this category of drugs might still represent a limitation for patients with economic constraints, by contributing to treatment discontinuation