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Thus, CDO1 is a metabolic liability for NSCLC cells with high intracellular cysteine, particularly NRF2/KEAP1 mutant cells (Kang et al., Elife 2019)

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Analogously, ML239 agonizes fatty acid 6 desaturase 2 (FADS2) activity to increase PUFA synthesis and ferroptosis sensitivity [49]

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