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Patients who are not tolerating the maximal dose of a once-weekly GLP-1 receptor agonist, or those who are switching once-weekly GLP-1 receptor agonists due to GI adverse effects, should delay the initiation of the new GLP-1 receptor agonist therapy until symptoms have resolved

Always discard any insulin that has been frozen or is past its 28-day in-use period

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Patients on antidiabetic medications, including insulin, should also be cautious, as L-Carnitine may improve insulin sensitivity and glucose metabolism, potentially requiring adjustments in antidiabetic medication dosages