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Addition of Saxagliptin to Metformin HCl Immediate-Release A total of 743 patients with type 2 diabetes mellitus participated in this 24-week, randomized, double-blind, placebo-controlled trial to evaluate the efficacy and safety of saxagliptin in combination with metformin HCl immediate-release in patients with inadequate glycemic control (A1C 7% and 10%) on metformin HCl alone

Redox regulation involves proteins and cofactors that maintain the appropriate redox environment for proper functioning of the cell (Ray et al., 2012), ensuring that there is a balance between the production of ROS, RNS, and their consequent elimination by antioxidant enzymes and smaller molecules

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