10.1038/s41420-023-01748-9 188 YangJ.DuC.LiY.LiuR.JingC.XieJ.et al (2024a)
Liu GJ, Middleton RJ, Kam WW, Chin DY, Hatty CR, Chan RH, Banati RB (2017) Functional gains in energy and cell metabolism after TSPO gene insertion
Certain chelators, such as alpha-lipoic acid, can cause redistribution of metals in the body
This interaction affects the expression of all the downstream targets causing significant metabolic depression, low cellular ATP content and, then, lipid accumulation ( FIGURE 2 Therapeutic Interventions for Rescuing Fatty Acid Oxidation As described above, dysfunctions of the mitochondrial -oxidation trigger kidney injury, therefore, mitochondria represent a potential drug target
For this reason, doctors evaluate not only body weight but also waist circumference, blood pressure, blood sugar, cholesterol, sleep apnea risk, and overall quality of life