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2010, 202: 239 e231-239 e210

Abstract Introduction: Kidney allograft fibrosis accelerates the progression of chronic kidney disease (CKD), leads to allograft failure, and increases patient mortality

Methotrexate is given once weekly (though oral tablets are also commonly used in the UK), whilst GLP-1 receptor agonists are typically administered subcutaneously once daily or once weekly, depending on the specific formulation

Friction surfaces earlier, before it has time to harden into margin pressure

It is speculated that this signaling may be mediated by CREB, which is known to act downstream of GLP-1R and may influence the transcription of IL-6 [122,123,124]