2.2.1 Interaction via receptors and transport SCFAs interact with host tissues through: GPCRs: GPR41 (FFAR3), GPR43 (FFAR2), GPR109A HDAC inhibition: Especially butyrate, influencing gene expression Monocarboxylate transporters (MCT1, MCT4): Mediate SCFA absorption into colonocytes
PubMed: 38937282 Wilding JPH, et al
It can also lead to issues with blood sugar levels and getting proper nutrition
Relative potency at the GIPR is 8.9 times that of native GIP, while at the glucagon receptor and GLP-1R it is 0.3 and 0.4 times native hormone potency, respectively [3]
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