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doi: 10.1038/s41467-018-06603-5 97 LiuXChenSLiuLChenY

Transcription factors such as nuclear factor erythroid related factor (Nrf2), nuclear factor kappa B (NF-kB), and AP-1 were reported to be activated by antioxidants such as curcumin, resveratrol, and quercetin (Wong et al., 2018)

Abbreviations AD: Alzheimers disease ALS: Amyotrophic lateral sclerosis AMPK: AMP-activated protein kinase BBB: Blood-brain barrier CNS: Central nerve system EAAT-1: Excitatory amino acid transporter 1 EAE: Experimental allergic encephalomyelitis H 2 O 2 : Hydrogen peroxide MCI: Mild cognitive impairment MS: Multiple sclerosis MSU: Monosodium urate mTOR: Mammalian target of rapamycin NO: Nitric oxide ONOO : Peroxynitrite PD: Parkinsons disease RNS: Reactive nitrogen species ROS: Reactive oxygen species SCI: Spinal cord injury SOD: Superoxide dismutase TFEB: Transcription factor EB TLR: Toll-like receptor UA: Uric acid VEGF: Vascular endothelial growth factor XO: Xanthine oxidase References Burtscher J, Millet GP, Place N, Kayser B, Zanou N

GHK (also known as tripeptide-1), comprising three amino acids, namely - glycine, histidine and lysine