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The 500 mcg per-capsule dose mirrors the per-day intake used in the bulk of rodent oral studies, and the gastric origin of the parent molecule provides a biological rationale for stability through the GI tract a feature documented across multiple oral-administration preclinical models

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HCC Mapping Cross-Reference Table 15

The author(s) declared that they were an editorial board member of Frontiers, at the time of submission

Pre-clinical data points to upregulation of nerve growth factor and vascular endothelial growth factor in injury models, supporting interest in nerve regeneration and angiogenesis applications