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The same study showed increased levels of glucose-dependent insulinotropic polypeptide (GIP), pancreatic polypeptide, and peptide YY (PYY) in POTS after oral glucose tolerance test, and there was a time-dependent correlation between levels of GIP and decreased stroke volume/increased HR after tilt test

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The peptides sequence allows researchers to explore cellular signaling cascades, gene expression modulation, and enzymatic sensitivity with a high degree of experimental control

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