Rho small GTPase family (rac1, cdc42, and rhoA) has an established role in mediating neurite growth and spine morphogenesis (Tashiro et al., 2000
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One could speculate that a key treatment strategy for progressive MS could involve targeting CNS-resident B cells, not aiming to suppress their traditional immunological (mis)behavior, but instead to quell a yet-to-be-discovered unconventional action, possibly related to secretion of an MS-specific myelin toxin into the CSF
