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Plants such as bracken ferns are problematic while toxicity symptoms vary widely based on dose, duration, and species of affected animals these plants contain thiaminases, and thiamine deficiency has been noted in sheep grazing on the plants in Australia

Before each injection, inspect the vial for particles, discoloration, or cloudiness, which indicate contamination or degradation

They also check Vitamin B12 levels and how the patient is doing to adjust the treatment as needed

In some cases, patients have reported issues such as ruined skin , usually due to excessive application or improper formulation