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Thus far, the PD analysis measuring CN activity has only been studied following the morning dose of twice-daily Tac formulation, but no data has reported the PD effect after the night dose

The results showed no histological alterations, indicative of the high biocompatibility and biosafety

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Phase I, pharmacokinetic, and pharmacodynamic study of AMG 479, a fully human monoclonal antibody to insulin-like growth factor receptor 1