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GIP receptors are found throughout the body, and their activation improves how cells respond to insulin (insulin sensitivity) and appears to promote more favorable fat distribution (less visceral fat around organs, more subcutaneous fat under the skin)

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oral as Rybelsus), dulaglutide (Trulicity), and liraglutide (Victoza, Saxenda)

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Early studies suggest retatrutide can deliver dramatic weight loss and preserve muscle